Tarun E. Hutchinson, PhD
Dr. Hutchinson’s prime focus is on plasma membrane surface proteins and lipid rafts signaling including GPI (Glycosyl phosphatidyl inositol) anchors and caveolae with special emphasis on lung epithelium (barrier function) and vascular endothelium function (Pulmonary Hypertension, Angiogenesis, Potocytosis). The cup shaped cholesterol enriched plasma membrane invagination caveolae housed multiple kinases, receptors, proteins, which are very specific in regulation of lung function, protection and maintaining immunity against external environment, foreign molecules and pathogens. Caveolin-1 the principal protein of caveolae plays a significant role in regulating the pulmonary function and maintaining the vascular tone. Current focus is on the mechanism of caveolar machinery in restoration of lung epithelium barrier function in vaccinia virus induced lung epithelium barrier dysfunction.